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THE STRIETER LAB

Chemistry and Biology of Protein Ubiquitination

We work at the interface of chemistry and biology to elucidate how the small protein ubiquitin controls the dynamics of biochemical pathways

Strieter Lab Overview: Welcome
Selected Publications

Shestoperova E.I., Ivanov D.G., Chien L., Strieter E.R.* Computationally Driven Top-Down Mass Spectrometry of Ubiquitinated Proteins. bioRxiv (2025). doi:10.1101/2025.07.24.666707.

Li Y., Chang L., Patel R., Shestoperova E.I., Du J., Das C., Strieter E.R.* Site-Specific Nanobody Inhibitors of the Proteasomal Deubiquitinase UCH37. bioRxiv (2025). doi:10.1101/2025.08.11.669711.

Du J., Babik S., Li Y., Deol K.K., Eyles S.J., Fejzo J., Tonelli M., Strieter E.R.* A Cryptic K48 Chain Binding Site on UCH37 is Required for its Role in Proteasomal Degradation. eLife 11 (2022): e76100.

Deol K.K., Crowe S.O., Du J., Bisbee H.A., Guenette R.G., Strieter E.R.* Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation. Molecular Cell 80 (2020): 796–809.

413-545-2937

University of Massachusetts Amherst
710 N Pleasant St
Amherst, MA 01003
USA

©2026 by Strieter Lab.

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